Brain Health Journey

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Identifying the problem

diagnosis confirmation

After an initial medical evaluation, in this stage the diagnostic process continues with additional healthcare clinician assessment, family input and medical history, imaging, and blood-based biomarker testing. A diagnosis is then made and confirmed based on this information. If other possible causes of brain health change are ruled out, the diagnosis may be mild cognitive impairment (MCI) or dementia due to Alzheimer’s disease.

After having an initial medical evaluation, what are the next steps to get a diagnosis?

You may need to complete multiple steps before reaching a final diagnosis. These could include referrals to specialists and additional labs or tests. Your clinician(s) will likely follow the steps below to move toward a diagnosis. While timing varies widely (these can take weeks, months, or longer), it's important to stay on the journey to get the answers you need.

Functional exam and detailed history — to measure your ability to function and complete daily activities and tasks, including input from family or close friends and validated cognitive testing.
Labs and tests — to identify potential reversible causes of your symptoms, along with brain imaging using positron emission tomography (PET) or cerebrospinal fluid (CSF) tests.

For example, your clinician(s) may do blood tests to check for identifiable problems such as low thyroid or B12, liver or kidney problems, anemia, and more.
Brain imaging might check for stroke, mass, fluid shifts, or possible infections.

Blood-based biomarker testing — blood tests to detect changes in your brain.

Before any appointment, check with your insurance provider to see what your plan covers. In most cases, brain imaging with PET or CSF tests is covered at least once to confirm a diagnosis and determine eligibility for the two disease-modifying therapies currently available.
If PET or CSF tests are not available, Medicare may cover a blood test to confirm the diagnosis. For Medicare Advantage, call 1-800-MEDICARE (1-800-633-4227) to check your coverage.

Bottom line: Getting a diagnosis often involves multiple steps and can take time, but each one brings you closer to answers and the right care. Don't hesitate to ask your clinician what to expect, and be sure to check with your insurance provider along the way.

What should I do during the appointment(s) to confirm my diagnosis?

I received an Alzheimer’s disease diagnosis. What stage am I in?

What should I do after receiving an Alzheimer’s disease diagnosis?

The information provided on this website is for general informational and educational purposes only and is not intended to constitute medical advice, diagnosis, or treatment. It should not be relied upon as a substitute for professional medical judgment. Consult a qualified healthcare provider with any questions you may have regarding Alzheimer's disease, related conditions, or any medical condition.

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